Chronology for the development of the concept of Probiotics
1953	Probiotics have common ingredients with vegetables - vitamins, aromatic substances, enzymes and possibly other substances related to life processes.
1954	Probiotics are seen as the opposite of antibiotics.
1955	The harmful effects of antibiotics can be avoided through probiotic therapy.
1965	Probiotics are substances secreted by some microorganisms that stimulate the growth of other microorganisms.
1971	Probiotics are tissue extracts that stimulate microbial growth.
1973	Probiotics are compounds that build the body's resistance to infections and do not inhibit the growth of microorganisms in vitro.
1974	Microorganisms and substances related to intestinal microbial balance.
1992	A living microbial food supplement that has a beneficial effect on the body by improving microbial balance.
1993	Live mono- or mixed culture of microorganisms, which has a beneficial effect on the body, improving the local microflora.
1996	Live microbial culture or dairy product that has a healthy effect on the body.
1997	Live microorganisms in sufficient quantities have a healthy effect in addition to the main diet.
1999	Microbial cell extracts beneficial to the health of the consumer.
2000	Microorganisms transiting the GIT promote the health of the body.
2001	Product containing certain living microorganisms in sufficient quantities, which affect the microflora through colonization, have a beneficial and healthy effect on the body.
2002	Probiotics are living microorganisms, taken in sufficient quantities have a healthy effect on the body.

Based on the concept thus formed, a significant number of microorganisms have been developed as probiotic supplements. They are broadly used for health supplements for humans and animals, for the treatment / prevention of specific diseases, physiological disorders and syndromes. Currently, a number of bacterial strains of different generation have been developed as probiotics. For example: Lactobacillus - 23; Bifidobacterium - 5, Echerischia coli - 2 and one strain of Bacillus, Streptococcus, Enterococcus, Lactococcus. In addition, a recognized strain of probiotics is the yeast strain Saccharomyces boulardii.